Melinda Gordon (Jennifer Love Hewitt) communicates with earthbound spirits, ghosts who cling to the living because they have unfinished business that prevents them from moving beyond the familiar plane of existence that we call life. Inspired in part by the work of famed medium James Van Praagh and of Mary Ann Winkowski, a real-life communicator with spirits, Ghost Whisperer explores the spiritual side of life and death as Melinda navigates among the dead and the living in her sometimes chilling, sometimes heart-rending and sometimes amusing attempts to act as an intermediary between the ghosts and those they haunt. Jim (David Conrad), her husband, worries about the emotional toll this work is taking on his wife as they embark on a new life together. Andrea, her friend and business partner in their antique store, is fascinated by Melinda's talent. Melinda is somewhat reluctant to reveal her "gift" to new friend Delia Banks (Camryn Manheim), a single mom who lives in Grandview, fearing the consequences of drawing her into this "unconventional" world. For her part, Melinda accepts her unique abilities as a blessing and sometime a curse, but always helps her clients alive or dead find emotional closure.